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Rüffer B, Thielmann Y, Lemke M, Minges A, Groth G (2024) Crystallization of Ethylene Plant Hormone Receptor—Screening for Structure. Biomolecules. doi: 10.3390/biom14030375

Lemke M, Reiners J, Smits SHJ, Lakomek N, Groth G (2023) Functional reconstitution and structural characterization of the plant hormone receptor ETR1 in lipid nanodiscs. Chemical Communications. doi: 10.1039/d3cc02619a

Azhar BJ, Abbas S, Aman S, Yamburenko MV, Chen W, Müller L, Uzun B, Jewell DA, Dong J, Shakeel SN, Groth G, Binder BM, Grigoryan G, Schaller GE (2023) Basis for high-affinity ethylene binding by the ethylene receptor ETR1 of Arabidopsis. PNAS. doi: 10.1073/pnas.2215195120

Dittrich J, Kolodzy F, Töpel A, Hofmann A, Groth G, Pich A, Gohlke H (2023) Loading and Co-Solvent-Triggered Release of Okanin, a C4 Plant Key Enzyme Inhibitor, into/from Functional Microgels. Chemical Engineering Journal. doi: 10.1016/j.cej.2023.141631.


Cutsail G, Schott-Verdugo S, Müller L, DeBeer S, Groth G & Gohlke H (2022) Spectroscopic and QM/MM studies of the Cu(I) binding site of the plant ethylene receptor ETR1. Biophys. J. doi: 10.1016/j.bpj.2022.09.007.

Lu J, Wen, C-K & Groth G (2022) New Insights into Phase Separation Processes and Membraneless Condensates of EIN2. Plants 11: 2149. doi: 10.3390/plants11162149

Gopalswamy M, Kroeger T, Bickel D, Frieg B, Akter S, Schott‑Verdugo S, Viegas A, Pauly T, Mayer M, Przibilla J, Reiners J, Nagel‑Steger L, Smits SHJ, Groth G, Etzkorn M & Gohlke H (2022) Biophysical and pharmacokinetic characterization of a small‑molecule inhibitor of RUNX1/ETO tetramerization with anti‑leukemic effects. Sci. Rep. 12:14158. doi: 10.1038/s41598-022-17913-6

Kugele A, Uzun B, Müller L, Schott-Verdugo S, Gohlke H, Groth G. (2022) Mapping the helix arrangement of the reconstituted ETR1 ethylene receptor transmembrane domain by EPR spectroscopy. RSC Adv. doi: 10.1039/D2RA00604A

Sauer DF, Wittwer M, Markel U, Minges A, Spiertz M, Schiffels J, Davari MD, Groth G, Okuda J, Schwaneberg U. (2021) Chemogenetic engineering of nitrobindin toward an artificial epoxygenase. Catal. Sci. Technol. doi: 10.1039/d1cy00609f

Hofmann A, Minges A, Groth G. (2021)B Interfering Peptides Targeting Protein–Protein Interactions in the Ethylene Plant Hormone Signaling Pathway as Tools to Delay Plant Senescence. In: Hicks G.R., Zhang C. (eds) Plant Chemical Genomics. Methods Mol. Biol. 2213. Humana, New York, NY. doi: 10.1007/978-1-0716-0954-5_7

B Book chapter

Minges A, Groth G. (2020)R Structure and supramolecular architecture of chloroplast ATP synthase. Adv Bot Res. 96; 27-74. doi: 10.1016/bs.abr.2020.07.004

Kawamoto N, Pino Del Carpio D, Hofmann A, Mizuta Y, Kurihara D, Higashiyama T, Uchida N, Torii KU, Colombo L, Groth G und Simon R (2020) A peptide pair coordinates regular ovule initiation patterns with seed number and fruit size. Current Biology 30: 4352-4361. doi: 10.1016/j.cub.2020.08.050

van Gils JHM, van Dijk E, Peduzzo A, Hofmann A, Vettore N, Schützmann MP, Mouhib H, Otzen DE, Büll AK, Abeln S. (2020) The hydrophobic effect characterises the thermodynamic signature of amyloid fibril growth. PLoS Comput. Biol 16(5): e1007767. doi: 10.1371/journal.pcbi.1007767

Hofmann A, Müller S, Drechsler T, Berleth M, Caesar K, Rohr L, Harter K, Groth G. (2020) High-Level Expression, Purification and Initial Characterization of Recombinant Arabidopsis Histidine Kinase AHK1. Plants 9(3):304. doi: 10.3390/plants9030304

Hoppen C, Groth G (2020). Novel insights into the transfer routes of the essential copper cofactor to the ethylene plant hormone receptor family. Plant Signal Behav 15(2):1716512. doi: 10.1080/15592324.2020.1716512

R Review

Minges A, Janßen D, Offermann S, Groth G. (2019) Efficient In Vivo Screening Method for the Identification of C4 Photosynthesis Inhibitors Based on Cell Suspensions of the Single-Cell C4 Plant Bienertia sinuspersici. Front Plant Sci. 2019 Oct 30. doi: 10.3389/fpls.2019.01350

Hoppen C, Müller L, Hänsch S, Uzun B, Milić D, Meyer AJ, Weidtkamp-Peters S, Groth G. (2019) Soluble and membrane-bound protein carrier mediate direct copper transport to the ethylene receptor family. Sci Rep. 2019 Jul 24. doi: 10.1038/s41598-019-47185-6

Schott-Verdugo S, Müller L, Classen E, Gohlke H, Groth G (2019) Structural Model of the ETR1 Ethylene Receptor Transmembrane Sensor Domain. Sci. Rep. 9: 8869. doi: 10.1038/s41598-019-45189-w

Hoppen C, Müller L, Albrecht AC, Groth G. (2019) The NOP-1 peptide derived from the central regulator of ethylene signaling EIN2 delays floral senescence in cut flowers. Sci Rep. 2019 February 9; 9:1287. doi: 10.1038/s41598-018-37571-x

Berleth M, Berleth N, Minges A, Hänsch S, Burkart RC, Stork B, Stahl Y, Weidtkamp-Peters S, Simon R and Groth G. (2019) Molecular Analysis of Protein Protein Interactions in the Ethylene Pathway in the Different Ethylene Receptor Subfamilies. Front Plant Sci. 2019 May 16 (accepted). doi: 10.3389/fpls.2019.00726

Klein S, Fiebig A, Noga G, Groth G, Hunsche M (2019) Ripening inhibitory effect of the ethylene signalling protein EIN2 derived octapeptide NOP-1 on tomatoes as influenced by repeated applications and applications at different ripening stages. Sci. Hortic. 254: 143-147. doi: 10.1016/j.scienta.2019.05.011

Klein S, Fiebig A, Neuwald D, Dluhosch D, Müller L, Groth G, Noga G, Hunsche M (2019) Influence of the NLS-derived octapeptide NOP-1 on postharvest ripening and fruit quality of ‘Golden Delicious’ Apples. J. Sci. Food Agric. 99: 3903. doi: 10.1002/jsfa.9613

Murakami S, Kondo K, Katayama S, Hara S, Sunamura E, Yamashita E, Groth G, Hisabori T (2018) Structure of the γ–ε complex of cyanobacterial F1-ATPase reveals a suppression mechanism of the γ subunit on ATP hydrolysis in phototrophs. Biochem. J. 475: 2925-2939. doi: 10.1042/BCJ20180481

Bhatia S, Diedrich D, Frieg B, Ahlert H, Stein S, Bopp B, Lang F, Zang T, Kröger T, Ernst T, Kögler G, Krieg A Lüdeke S, Kunkel H, Rodrigues Moita AJ, Kassack MU, Marquardt V, Opitz FV, Oldenburg M, Remke M, Babor F, Grez M, Hochhaus A, Borkhardt A, Groth G, Nagel-Steger L, Jose J, Kurz T, Gohlke H, Hansen FK, Hauer J (2018) Targeting HSP90 dimerization via the C-terminus is effective in imatinib resistant CML and lacks heat shock response. Blood 132: 307-320. doi: 10.1182/blood-2017-10-810986

Milić D, Dick M, Mulnaes D, Pfleger C, Kinnen A, Gohlke H, Groth G. (2018) Recognition motif and mechanism of ripening inhibitory peptides in plant hormone receptor ETR1. Sci Rep. 2018 March 3; 8:3890. doi: 10.1038/s41598-018-21952-3

Rühlmann A, Groth G, Urlacher VB (2017) Characterization of CYP154F1 from Thermobifida fusca YX and extension of its substrate spectrum by site-directed mutagenesis. ChemBioChem 19: 478-485. doi: 10.1002/cbic.201700565

Dick M, Erlenkamp G, Nguyen GTT, Förster K, Groth G, Gohlke H. (2017) Pyrazolidine‐3,5‐dione‐based inhibitors of phosphoenolpyruvate carboxylase as a new class of potential C4 plant herbicides. FEBS Lett. 591: 3369-3377. doi: 10.1002/1873-3468.12842

Kessenbrock M, Klein SM, Müller L, Hunsche M, Noga G, Groth G. (2017) Novel Protein-Protein Inhibitor Based Approach to Control Plant Ethylene Responses: Synthetic Peptides for Ripening Control. Front Plant Sci. 2017 Sep 5;8:1528. doi: 10.3389/fpls.2017.01528

Minges A, Groth G. (2017) Small-molecule inhibition of pyruvate phosphate dikinase targeting the nucleotide binding site. PLoS One. 2017 Jul 10;12(7):e0181139. doi: 10.1371/journal.pone.0181139

Minges A, Höppner A, Groth G. (2017) Trapped intermediate state of plant pyruvate phosphate dikinase indicates substeps in catalytic swiveling domain mechanism. Protein Sci. 2017 May 3. doi: 10.1002/pro.3184

Kroeger T, Frieg B, Zhang T, Hansen FK, Marmann A, Proksch P, Nagel-Steger L, Groth G, Smits SHJ, Gohlke H (2017) EDTA aggregates induce SYPRO orange-based fluorescence in thermal shift assay. PLoS ONE 12:e0177024. doi: 10.1371/journal.pone.0177024

Minges A, Ciupka D, Winkler C, Höppner A, Gohlke H, Groth G. (2017) Structural intermediates and directionality of the swiveling motion of Pyruvate Phosphate Dikinase. Sci Rep. 2017 Mar 30;7:45389. doi: 10.1038/srep45389

Kessenbrock M, Groth G (2017) Circular Dichroism and Fluorescence Spectroscopy to Study Protein Structure and Protein-Protein Interactions in Ethylene Signaling. Methods Mol Biol. 1573:141-159. doi: 10.1007/978-1-4939-6854-1_12

Bisson MM, Kessenbrock M, Müller L, Hofmann A, Schmitz F, Cristescu SM, Groth G. (2016) Peptides interfering with protein-​protein interactions in the ethylene signaling pathway delay tomato fruit ripening. Sci Rep. 6:30634. doi: 10.1038/srep30634

Nguyen GTT, Erlenkamp G, Jäck O, Küberl A, Bott A, Fiorani F, Gohlke H, Groth G. (2016) Chalcone-based Selective Inhibitors of a C 4 Plant Key Enzyme as Novel Potential Herbicides. Sci. Rep. 6:27333. doi: 10.1038/srep27333

Bopp B, Ciglia E, Ouald-Chaib A, Groth G, Gohlke H. (2016) Design and biological testing of peptidic dimerization inhibitors of human Hsp90 that target the C-terminal domain. Biochim. Biophys. Acta 6:1043-1055. doi: 10.1016/j.bbagen.2016.01.005

Bisson MMAGroth G. (2015) Targeting Plant Ethylene Responses by Controlling Essential Protein-Protein Interactions in the Ethylene Pathway. Mol Plant. 8: 1165-1174. doi: 10.1016/j.molp.2015.03.014

Schlieper D, Förster K, Paulus JK, Groth G. (2014) Resolving the Activation Site of Positive Regulators in Plant Phosphoenolpyruvate Carboxylase. Mol. Plant 7: 437-440. doi: 10.1093/mp/sst130

Paulus JK, Förster K & Groth G (2014) Direct and selective small-molecule inhibition of photosynthetic PEP carboxylase: New approach to combat C4 weeds in arable crops. FEBS Lett. 588: 2101-2106. doi 10.1016/j.febslet.2014.04.043

Aldous SH, Weise SE, Sharkey TD, Waldera-Lupa DM, Stühler K, Mallmann J, Groth G, Gowik U, Westhoff P & Arsova B (2014) Evolution of the phosphoenolpyruvate carboxylase protein kinase family in C3 and C4 Flaveria species. Plant Physiol. 165: 1076-1091. doi: 10.1104/pp.114.240283

Esser C, Kuhn A, Groth G, Lercher MJ & Maurino VG (2014) Plant and animal glycolate oxidases have a common eukaryotic ancestor and convergently duplicated to evolve long-chain 2-hydroxy acid oxidases. Mol. Biol. Evol. 31: 1089-1101. doi: 10.1093/molbev/msu041

Ciglia E, Vergin J, Reimann S, Smits SHJ, Schmitt L, Groth G & Gohlke, H. (2014) Resolving Hot Spots in the C-Terminal Dimerization Domain that Determine the Stability of the Molecular Chaperone Hsp90. PLoS ONE 9: e96031. doi: 10.1371/journal.pone.0096031

Paulus JK, Schlieper D, Groth G (2013) Greater efficiency of photosynthetic carbon fixation due to single amino-acid substitution. Nat. Commun. 4: 1518. doi: 10.1038/ncomms2504

Paulus JK, Niehus C, Groth G. (2013) Evolution of C4 Phosphoenolpyruvate Carboxylase: Enhanced Feedback Inhibitor Tolerance Is Determined by a Single Residue. Mol. Plant 6: 1996-1999. doi: 10.1093/mp/sst078

Classen E & Groth G. (2012) Cloning, expression and purification of orthologous membrane proteins: a general protocol for preparation of the histidine sensor kinase ETR1 from different species. Mol. Membr. Biol. 29: 26-35. doi: 10.3109/09687688.2012.667576

Bisson MMA, Groth G. (2012) Cyanide is an adequate agonist of the plant hormone ethylene for studying signalling of sensor kinase ETR1 at the molecular level. Biochem. J. 444: 261-267 doi: 10.1042/BJ20111447

Ju C, Mee Yoon G, Shemansky JM, Lin DY, Ying I, Chang J, Garret WM, Kessenbrock M, Groth G, Tucker ML, Cooper B, Kieber JJ, Chang C. (2012) CTR1 phosphorylates the central regulator EIN2 to control ethylene hormone signaling from the ER membrane to the nucleus in Arabidopsis. PNAS 109: 19486-19491. doi: 10.1073/pnas.1214848109

Gohlke H, Schlieper D & Groth G. (2012) Resolving the n-side water accessible proton pathway of F-type ATP synthase by molecular dynamics simulations. J. Biol. Chem. 287: 36536-36543. doi: 10.1074/jbc.M112.398396

Bisson MMA, Groth G. (2011) New paradigm in ethylene signaling. Plant Signal & Behav. 6(1): 164-166. doi: 10.4161/psb.6.1.14034

Scharein B, Groth G. (2011) Phosphorylation Alters the Interaction of the Arabidopsis Phosphotransfer Protein AHP1 with Its Sensor Kinase ETR1. PLoS ONE 6(9): e24173. doi: 10.1371/journal.pone.0024173

Dong CH, Jang M, Scharein B, Malach A, Rivarola M, Liesch J, Groth G, Hwang I, Chang C. (2010) Molecular association of the Arabidopsis ETR1 ethylene receptor and a regulator of  ethylene signaling RTE1. J. Biol. Chem. 2857: 40706-40713 doi: 10.1074/jbc.M110.146605

Bisson MMA & Groth G. (2010) New Insight in Ethylene Signaling: Autokinase Activity of ETR1 Modulates the Interaction ofReceptors and EIN2. Mol Plant 3(5): 882–889. doi: 10.1093/mp/ssq036

Bisson MMA, Bleckmann AAllekotte SGroth G (2009) EIN2, the central regulator of ethylene signalling, is localized at the ER membrane where it interacts with the ethylene receptor ETR1. Biochem. J.  424: 1–6. doi: 10.1042/BJ20091102

Vollmar M, Schlieper D, Winn M, Büchner C und Groth G. (2009) Structure of the c14 Rotor Ring of the Proton Translocating Chloroplast ATP Synthase. J. Biol. Chem. 284(27): 18228–18235. doi: 10.1074/jbc.M109.006916

Voet-​van-Vormizeele J Groth G. (2008)R Mutants, molecules and mechanisms – Deciphering the ethylene signalling network. Curr Top Biochem Res 10(2): 25 - 34

Meiß E, Konno H, Groth G, Hisabori T. (2008) Molecular processes of inhibition and stimulation of ATP synthase caused by the phytotoxin tentoxin. J Biol Chem. 283: 24594-24599. doi: 10.1074/jbc.M802574200

Scharein B, Voet van Vormizeele J, Harter K, Groth G. (2008) Ethylene signalling: Identification of a putative ETR1-AHP1 phosphorelay complex by fluorescence spectroscopy. Anal Biochem. 377(1):72-6. doi: 10.1016/j.ab.2008.03.015

Voet van Vormizeele J. & Groth G. (2008) Ethylene controls autophosphorylation of the histidine kinase domaine in ethylene receptor ETR1. Mol Plant 1: 380-387. doi: 10.1093/mp/ssn004

R Review 

van Lis R, Mendoza-Hernández G, Groth G, Atteia A. (2007) New insights into the unique structure of the F0F1-ATP synthase from the chlamydomonad algae Polytomella sp. and Chlamydomonas reinhardtii. Plant Physiol. 144(2):1190-9. doi: 10.1104/pp.106.094060

Lill H., Hisabori T, Groth G, Bald D. (2004) A thermo-stable enzyme as an experimental platform to study properties of less stable homologues. Protein Engineering, Design and Selection 17: 553‑555. doi: 10.1093/protein/gzh069

Pavlova P, Shimabukuro K, Hisabori T, Groth G, Lill H, Bald D. (2004) Complete inhibition and partial re-activation of single F1-ATPase molecules by tentoxin: New properties of the re-activated enzyme. J. Biol. Chem. 279: 9685-9688. doi: 10.1074/jbc.C400014200

Voet van Vormizeele J & Groth G. (2003) High-level Expression of the Arabidopsis thaliana ethylene receptor protein ETR1 in Escherichia coli and purification of the recombinant protein. Protein Expression and Purification 32(1): 89-94. doi: 10.1016/S1046-5928(03)00215-8

Groth G. (2003)R Chloroplast F1-ATPase: Structure and Regulation. Recent Research Developments in Biochemistry 4: 903-914.  

Schnick C, Koertgen N,  Groth G. (2002) Complete inhibition of the tentoxin resistant F1-ATPase from Escherichia coli by the phytopathogenic inhibitor tentoxin after substitution of critical residues in the alpha- and beta-subunit. J. Biol. Chem. 277: 51003-51007. doi: 10.1074/jbc.m206095200

Groth G, Hisabori T, Lill H, Bald, D. (2002) Substitution of a single amino acid switches the tentoxin resistant thermophilic ATP synthase into a tentoxin sensitive enzyme. J. Biol. Chem. 277: 20117-20119. doi: 10.1074/jbc.C200168200

Groth G. (2002) Structure of spinach chloroplast F1-ATPase complexed with the phytopathogenic inhibitor tentoxin. Proc. Natl. Acad. Sci. USA, 99(6): 3464-3468. doi: 10.1073/pnas.052546099

Groth G & Pohl E. (2001) The Structure of the Chloroplast F1-ATPase at 3.2 Å Resolution. J. Biol. Chem. 276: 1345-1352. doi: 10.1074/jbc.M008015200

Groth G. (2000)R Molecular models of the structural arrangement of subunits and the mechanism of proton translocation in the membrane domain of F1Fo ATP synthase. In special issue "The mechanism of F1Fo-ATPase" Biochim. Biophys. Acta  1458: 417-427. doi: 10.1016/S0005-2728(00)00091-8

Groth G, Mills DA, Christiansen E, Richter ML, Huchzermeyer B. (2000) Characterization of a Phosphate Binding Domain on the alpha-subunit of Chloroplast ATP Synthase Using the Photoaffinity Phosphate Analog 4-azido-2-nitro-phenylphosphate. Biochemistry 39: 13781-13787. doi: 10.1021/bi000991t

Schnick C, Forrest LR, Sansom MSP, Groth G. (2000) Molecular contacts in the transmembrane c-oligomer of F-ATPases identified by Tryptophan substitution mutagenesis. Biochim. Biophys. Acta  1459: 49-60. doi: 10.1016/S0005-2728(00)00112-2

Groth G & Strotmann H. (1999)R New results about structure, function and regulation of the chloroplast ATP synthase (CF0CF1). Physiologia Plantarum 106: 142-148. doi: 10.1034/j.1399-3054.1999.106120.x

Groth G & Schirwitz K. (1999) Rapid purification of membrane extrinsic F1-domain of chloroplast ATP synthase in monodisperse form suitable for 3D-crystallization. Eur. J. Biochem. 260: 15-21. doi: 10.1046/j.1432-1327.1999.00101.x

Groth G, Tilg Y, Schirwitz K. (1998) Molecular architecture of the c-subunit oligomer in the membrane domain of F-ATPases probed by tryptophan substitution mutagenesis. J. Mol. Biol. 281: 49-59. doi: 10.1006/jmbi.1998.1936

Groth G & Walker JE. (1997) Model of the c-subunit oligomer in the membrane domain of F‑ATPases. FEBS Letters: 410: 117-123. doi: 10.1016/S0014-5793(97)00529-2

Häsler KM, Fritsche O, Groth G, Junge W. (1996) ATP Synthase: Driven and Activated by Protonmotive Force. Ber. Bunsenges. Phys. Chem. 100: 2024-27. doi: 10.1002/bbpc.19961001217

Groth G & Walker JE. (1996) ATP synthase from bovine heart mitochondria: reconstitution into unilamellar phosholipid vesicles of the pure enzyme in a functional state. Biochem. J.: 318: 351-357. doi: 10.1042/bj3180351

Groth G & Junge W. (1995) ATP synthase: activating versus catalytic proton transfer. FEBS Letters 358: 142-144. doi: 10.1016/0014-5793(94)01414-V

Groth G & Junge W. (1995) ATP Synthase of Chloroplasts: Selective Action of Agents Binding to F1 on partial Reactions of Proton Transfer in F0. Biochemistry 34: 8589-8596. doi: 10.1021/bi00027a008

R Review